pbpk modelling tool (Simcyp)
90
Structured Review
Simcyp
pbpk modelling tool
Pbpk Modelling Tool, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pbpk+modeling+tools/pbpk+model/pm38142123-38-2-6
Average 90 stars, based on 1 article reviews
Pbpk Modelling Tool, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pbpk+modeling+tools/pbpk+model/pm38142123-38-2-6
Average 90 stars, based on 1 article reviews
pbpk modelling tool - by Bioz Stars,
2026-09
90/100 stars
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Drug discovery:Article Title: Poster Abstracts Article Snippet: Poster Abstracts Clinical Proteomics:Article Title: Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models. Article Snippet: The aim of this study was to evaluate a strategy based on static and dynamic physiologically based pharmacokinetic (PBPK) modeling for the prediction of metabolite and parent drug area under the timeconcentration curve ratio (AUCm/AUCp) and their PK profiles in humans using in vitro data when active transport processes are involved in disposition.. The strategy was applied to losartan and its pharmacologically active metabolite carboxylosartan as test compounds.. Hepatobiliary transport including transport-mediated uptake, canilicular and basolateral efflux, and metabolic clearance estimates were obtained from in vitro studies using human liver microsomes and sandwich-cultured hepatocytes. Concentration Assay:Article Title: Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models. Article Snippet: The aim of this study was to evaluate a strategy based on static and dynamic physiologically based pharmacokinetic (PBPK) modeling for the prediction of metabolite and parent drug area under the timeconcentration curve ratio (AUCm/AUCp) and their PK profiles in humans using in vitro data when active transport processes are involved in disposition.. The strategy was applied to losartan and its pharmacologically active metabolite carboxylosartan as test compounds.. Hepatobiliary transport including transport-mediated uptake, canilicular and basolateral efflux, and metabolic clearance estimates were obtained from in vitro studies using human liver microsomes and sandwich-cultured hepatocytes. Permeability:Article Title: Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models. Article Snippet: The aim of this study was to evaluate a strategy based on static and dynamic physiologically based pharmacokinetic (PBPK) modeling for the prediction of metabolite and parent drug area under the timeconcentration curve ratio (AUCm/AUCp) and their PK profiles in humans using in vitro data when active transport processes are involved in disposition.. The strategy was applied to losartan and its pharmacologically active metabolite carboxylosartan as test compounds.. Hepatobiliary transport including transport-mediated uptake, canilicular and basolateral efflux, and metabolic clearance estimates were obtained from in vitro studies using human liver microsomes and sandwich-cultured hepatocytes. |